Prednisolone-loaded nanocapsules as ocular drug delivery system: development,in vitrodrug release and eye toxicity
作者： Tatiele Katzer , Paula Chaves , Andressa Bernardi , Adriana Pohlmann , Silvia S. Guterres
DOI: 10.3109/02652048.2013.879930
关键词: Chorioallantoic membrane 、 Materials science 、 Controlled release 、 Drug delivery 、 Prednisolone 、 Nanoparticle tracking analysis 、 Nanocapsules 、 Toxicity 、 Cytotoxicity 、 Pharmacology 、 Physical and Theoretical Chemistry 、 Colloid and Surface Chemistry 、 Organic chemistry 、 Bioengineering 、 Pharmaceutical Science
摘要: AbstractObjective: To develop non-toxic aqueous ocular drug delivery systems containing prednisolone by means of its nanoencapsulation. Materials and methods: Nanocapsules were prepared interfacial deposition preformed polymer [poly(e-caprolactone) or Eudragit® RS100]. Particle size distribution was determined laser diffractometry, photon correlation spectroscopy nanoparticle tracking analysis. Ocular irritation cytotoxicity evaluated in vitro on the chorioallantoic membrane (CAM) rabbit corneal epithelial cell line, respectively. Results discussion: showed mean particle sizes between 100 300 nm encapsulation efficiency around 50%. Controlled release occurred for 5 h both formulations according to biexponential model. Both found be non-irritant CAM test non-cytotoxic toward cells. Conclusions: Encapsulation nanocapsules reported the...
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