Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

摘要: Abstract A second distinct family of anion transporters, in addition to the classical SLC4 (or AE) family, has recently been delineated. Members SLC26 are structurally well conserved and can mediate electroneutral exchange Cl − for HCO 3 across plasma membrane mammalian cells like members family. Three human transporter proteins have functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), SLC26A4 (PDS) transport with different specificities chloride, iodine, bicarbonate, oxalate, hydroxyl anions, whereas SLC26A5 (prestin) was suggested act as motor protein cochlear outer hair cell. We report expansion five new chromosomes 3, 6, 8, 12, 17 mapping SLC26A1 4p16.3. characterized one them, SLC26A6, more detail. It maps chromosome 3p21.3, encodes a predicted 738-amino-acid transmembrane protein, is most abundantly expressed kidney pancreas. Pancreatic ductal cell lines Capan-1 Capan-2 express immunohistochemistry localizes SLC26A6 apical surface pancreatic cells, suggesting it candidate luminal exchanger. The functional characterization novel this tissue-specific gene may provide insights into physiology parts body.