The Roles of Map Kinases in Controling Cancer Metastasis
作者： Alessandro Alessandrini
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摘要: The MAP kinases have been implicated in cell growth and differentiation. Dysregulation of these pathways results the increased incidence tumorgenicity metastasis. mechanisms by which lead to cancer yet be elucidated. Recently, Taguchi et al. shown that blocking interaction receptor for advanced glycation end products (RAGE) its ligand, amphoterin various strategies, such as administration soluble, extracellular region RAGE, resulted reduction tumour volume metastases mice (95). interestingly, inhibition RAGE-amphoterin decreased ERK1/2, SAPK, p38 kinase activities, reduced expression MMP-2 MMP-9
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