Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease
作者： Eugenia Papalexi , Anna Persson , Maria Björkqvist , Åsa Petersén , Ben Woodman
DOI: 10.1111/J.1460-9568.2005.04324.X
关键词:
摘要: Reductions in testosterone and luteinizing hormone levels reduced sexual functions have been reported Huntington's disease (HD) patients. Atrophy of the reproductive organs loss fertility also observed R6/2 mouse, which is currently most studied transgenic model HD. In an effort to define cause infertility we expression gonadotropin-releasing (GnRH) medial septum, diagonal band Broca hypothalamus male mice during maturation. We found a progressive reduction numbers GnRH-immunoreactive neurons analysed brain areas starting at 5 weeks age becoming statistically significant with only 10% remaining by 9 age. testes seminal vesicles combined serum testicular were detected 12-week-old R6/2mice. These results suggest that males due either death GnRH or leading downstream impairment gonadotropic hormones. Gonadotropic replacement did not mitigate weight restore motor function males.
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