Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

摘要: Background: This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) 3 common cancers (breast, lung colorectal) Thai patients. Materials Methods: Two hundred eighty colorectal, 101 breast 113 cancer patients recruited from one institute during 2011-2013. The controls age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels compared among different genotypes 2 SNPs. Results: minor allele frequencies (G) (A) 0.32 0.24, respectively. Under dominant model, found significant minor-allele SNP (TG/GG) (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according sex age at diagnosis, that minorallele significantly associated with colorectal whose diagnosis more than 60 years (OR 1.67, 95%CI 1.06-2.61) (CA/AA) males aged or less 2.34, 1.25-4.37). combinations (rs7041-rs4588) examined, TT-CA combination protective association 0.44, 0.22-0.85). On evaluation serum 25(OH)D 205 individuals without (males 144, females 61), proportion subjects low (< 20 ng/ml) those harboring CA AA (41.7%) higher CC genotype (15.5%, p-value < 0.01). Conclusions: Genetic Gc Lower variants may explain this association.