Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system.
作者： Nicholas S Kirkby , Martina H Lundberg , Louise S Harrington , Philip DM Leadbeater , Ginger L Milne
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摘要: Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It widely believed that COX-2 drives prostacyclin and this explains cardiovascular toxicity associated with inhibition, yet evidence for relies indirect from urinary metabolites. Here we have used a range experimental approaches to explore isoform in vitro vivo. Our data show unequivocally under physiological conditions it COX-1 not system, metabolites do reflect systemic circulation. With idea endothelium healthy individuals removed, must seek new answers why inhibitors increase risk events move forward drug discovery enable more informed prescribing advice.
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