Stroke: development, prevention and treatment with peptidase inhibitors.

摘要: Stroke is the leading cause of long-term disability in United States and affects more people than any other neurologic disorder. Hypertension a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension reduce morbidity mortality Previous experimental studies shown reduced stroke angiotensin-converting enzyme (ACE) inhibitors. This review discusses development potential use ACE inhibitors prevention treatment this disease. Furthermore, focuses on current investigations aimed at cellular mechanisms involved stroke-induced microvascular alterations.