REMODELATGE DE LA CROMATINA DURANT LA INDUCCIÓ PER PROGESTERONA DEL PROMOTOR DE L'MMTV
作者： Cecilia Ballaré , Miguel Beato , Guillermo P. Vicent , A. Silvina Nacht , Jaume Clausell
DOI:
关键词:
摘要: Per a comprendre els mecanismes que governen l'expressio dels gens inclosos en genomes eucariotics es necessari prendre consideracio la manera les regions reguladores d'aquests estan organitzades cromatina. Les diferencies l'organitzacio de cromatina i modificacions quimiques components cromatina expliquen diferents patrons genica diversos tipus cell. ules i seva resposta especifica senyals externs. Basant-nos nostres estudis sobre induccio hormonal del promotor mouse mammary tumour virus (MMTV), podem concloure sequencia nucleotidica primaria determina no solament doble helix DNA envolta l'octamer d'histona, i aixi l'accessibilitat punts d'unio per als factors transcripcio, sino tambe en que aquests estableixen sinergismes naturalesa remodelatge dependent d'ATP. A mes, senyalitzacio via crosstalk amb cascades cinases citoplasmatiques canvia l'estructura diana fonamental correcta regulacio a traves receptors d'hormones esteroidees.
unirioja.es参考文章(26)
A.C. Cato, D. Henderson, H. Ponta, The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region. The EMBO Journal. ,vol. 6, pp. 363- 368 ,(1987) , 10.1002/J.1460-2075.1987.TB04763.X
H. Richard-Foy, G. L. Hager, Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. The EMBO Journal. ,vol. 6, pp. 2321- 2328 ,(1987) , 10.1002/J.1460-2075.1987.TB02507.X
M. Truss, J. Bartsch, A. Schelbert, R.J. Haché, M. Beato, Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo. The EMBO Journal. ,vol. 14, pp. 1737- 1751 ,(1995) , 10.1002/J.1460-2075.1995.TB07163.X
A. Migliaccio, M. Di Domenico, G. Castoria, A. de Falco, P. Bontempo, E. Nola, F. Auricchio, Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. The EMBO Journal. ,vol. 15, pp. 1292- 1300 ,(1996) , 10.1002/J.1460-2075.1996.TB00471.X
U. Brüggemeier, L. Rogge, E. L. Winnacker, M. Beato, Nuclear factor I acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding. The EMBO Journal. ,vol. 9, pp. 2233- 2239 ,(1990) , 10.1002/J.1460-2075.1990.TB07393.X
Guillermo P. Vicent, A.Silvina Nacht, Corey L. Smith, Craig L. Peterson, Stefan Dimitrov, Miguel Beato, DNA Instructed Displacement of Histones H2A and H2B at an Inducible Promoter Molecular Cell. ,vol. 16, pp. 439- 452 ,(2004) , 10.1016/J.MOLCEL.2004.10.025
Toshio Tsukiyama, Carl Wu, Purification and properties of an ATP-dependent nucleosome remodeling factor Cell. ,vol. 83, pp. 1011- 1020 ,(1995) , 10.1016/0092-8674(95)90216-3
Antimo Migliaccio, Domenico Piccolo, Gabriella Castoria, Marina Di Domenico, Antonio Bilancio, Maria Lombardi, Wenrong Gong, Miguel Beato, Ferdinando Auricchio, Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. The EMBO Journal. ,vol. 17, pp. 2008- 2018 ,(1998) , 10.1093/EMBOJ/17.7.2008
Georges Chalepakis, Jutta Arnemann, Emily Slater, Hans-Joachim Brüller, Bernhard Gross, Miguel Beato, Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus Cell. ,vol. 53, pp. 371- 382 ,(1988) , 10.1016/0092-8674(88)90157-2
Gabriella Castoria, Maria Vittoria Barone, Marina Di Domenico, Antonio Bilancio, Donatella Ametrano, Antimo Migliaccio, Ferdinando Auricchio, Non-transcriptional action of oestradiol and progestin triggers DNA synthesis The EMBO Journal. ,vol. 18, pp. 2500- 2510 ,(1999) , 10.1093/EMBOJ/18.9.2500