Use of bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative pulmonary tuberculosis.
作者： H. Li , L. Yang , C-Y. Zheng , J. Wang , A. S. Abdullah
关键词:
摘要: Objective To compare the diagnostic validity of blood enzyme-linked immunospot assay (ELISpot), broncho-alveolar lavage (BAL) ELISpot and tuberculin skin test (TST) in patients with pulmonary smear-negative tuberculosis (TB) a country high TB prevalence. Design In prospective, hospital-based study, 107 suspected were tested simultaneously using BAL TST. Results Of 102 active TB, 36 (35.3%) diagnosed while 66/102 (64.7%) had non-TB diagnosis. The sensitivity specificity for on mononuclear cells from fluid was respectively 94.4% (95%CI 81.9-98.5) 78.1% 66.6-86.5). significantly higher than that (P = 0.011). Compared TST, not influenced by previous history (OR 2.05, P > 0.05) or household contact patient 2.41, 0.05). Conclusion appears to be more rapid sensitive supplementary diagnosis negative sputum smear developing setting prevalence access bronchoscopy assay. However, test's utility limited its moderate specificity.
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