Intravenous versus intracoronary streptokinase in acute myocardial infarction

摘要: Abstract One hundred sixty-four consecutive patients with acute myocardial infarction were enrolled in a prospective trial of coronary thrombolysis streptokinase (STK). The first 98 received intracoronary(i.c.) STK after angiography and the next 66 high-dose rapid infusion (900,000 IU) intravenously (i.v.) before angiography. First-pass radionuclide ejection fraction (EF) was performed early (within 24 hours admission late (10 to 14 days admission) evaluate left ventricular function. In i.v. group, 42 (64%) infarct-related arteries patent at initial angiogram 6 (9%) opened subsequent i.c. STK. 13 (13%) 50 85 (59%) groups did not differ time from onset chest pain presentation, type infarct or underlying severity artery disease. begun 67 minutes earlier than group. 62 whom reperfusion successful, mean EF increased 39 ± 11% 48 13% late. 30 it not, 36 ±10% 40 12%. increase significantly greater reperfused group (p