Nitrone radical traps protect in experimental neurodegenerative diseases
作者： Robert A. Floyd , John M. Carney
DOI: 10.1016/B978-012525445-8/50007-2
关键词:
摘要: Publisher Summary This chapter describes protective role of nitrone radical traps (NRT) in experimental neurodegenerative diseases. Oxygen free radicals and oxidative damage are involved brain aging, as well the age-related diseases, such stroke, Parkinson's disease, Alzheimer's disease. It is likely that NRTs react with hence quench primary reactive oxygen species and/or subsequently produced secondary radicals, which arise thus decrease stress imposed. When there a large then act to minimize cascade events, leads tissue injury. Alpha-phenyl- N - tert -butyl when administered chronically at 32 mg kg −1 twice daily old gerbils caused age-associated increase oxidized protein observed young animals mediate almost complete restoration glutamine synthetase neutral protease activity. scavenging critical prevent chain radical/oxidative processes, which, if unabated, lead damage. The protein, occurs result chronic administration NRTs, offers clues biological adaptation new state.
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