Cholecystokinin and insulin regulate insulin-like growth factor II binding to pancreatic receptors; evidence of a role for intracellular calcium.
作者： Neus Potau , Joachim Mössner , John A. Williams , Ira D. Goldfine
DOI: 10.1016/0006-291X(84)91659-0
关键词:
摘要: The binding of 125I-labeled insulin-like growth factor II (125I-IGF II) to mouse pancreatic acini was stimulated (45%) by insulin and inhibited (30%) cholecystokinin octapeptide (CCK8). When CCK8 were added together, the effect on IGF similar that seen when alone. Two lines evidence suggest this basal insulin-stimulated 125I-IGF mediated via a change in intracellular calcium: (1) cholinergic agent carbachol its receptors; (2) addition Ca2+ ionophore A23187 mimicked effects carbachol. In contrast acini, had only small I no binding.
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