Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.

作者: Huifen Wang , Ryan Dick , Hequn Yin , Estefania Licad-Coles , Deanna L. Kroetz

DOI: 10.1021/BI980895G

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摘要: … In addition, some of these P450 3A4 mutations that affected AFB1 regioselectivity had little influence on testosterone 6β-hydroxylation, thereby confirming that each substrate−…

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