Selective neuronal vulnerability in HIV encephalitis.

摘要: Recent studies of human immunodeficiency virus type 1 (HIV-1) encephalitis have shown that in addition to well established white matter damage, the neocortex shows thinning, loss large neurons and dendritic damage. In order identify neuronal populations affected HIV determine how damage relates severity infection within nervous system, we quantified parvalbumin (PV+) neurofilament (NF+) immunoreactive frontal cortex hippocampus. We found neocortex, density NF+ PV+ was independent encephalitis, therefore changes these subsets did not account for previously reported loss. However, neuritic processes were fragmented, atrophic some cases distended. contrast cortex, there a trend toward decreased hippocampus which only reached significance CA3 layer where 50-90% decrease neurons. This closely correlated with encephalitis. Double-label immunocytochemical analysis confirmed interneurons. These results suggest differentially involves specific subpopulations Since direct cells detected, fibers may be indirectly mediated by cytokines released HIV-infected microglia.