Dopamine receptor D2 (DRD2), dopamine transporter solute carrier family C6, member 4 (SLC6A3), and catechol-O-methyltransferase (COMT) genes as moderators of the relation between maternal history of maltreatment and infant emotion regulation.

摘要: Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects their environment), the use strategies at this age (as opposed relying on caregivers) is associated with elevated behavioral physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], catechol-O-methyltransferase [COMT]) as they interact maternal self-reported history maltreatment predict observed independent emotion regulation behavior. A community sample (N = 193) mother–infant dyads participated a toy frustration challenge 15 months, was coded. Buccal cells were collected for genotyping. Maternal significantly interacted SLC6A3 COMT genotypes, such that more 10-repeat valine alleles COMT, respectively, relative fewer or no alleles, utilized (i.e., maladaptive) regulatory if mother reported extensive history, less. The findings indicate child genetic factors moderate intergenerational impact history. results discussed terms potential mechanism Gene × Environment interaction.