Newer potential biomarkers in prostate cancer.
作者： Jonathan L. Wright , Paul H. Lange
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摘要: Prostate-specific antigen (PSA) screening has led to a significant rise in the number of men diagnosed with prostate cancer and an associated increase biopsies performed. Despite its limitations, including positive predictive value only 25%–40%, PSA remains generally accepted biomarker for cancer. There is need better tools not identify cancer, but also recognize those potentially lethal disease who will benefit from intervention. A great deal work been done worldwide improve our knowledge genetics behind specificity by developing assays different isoforms. Common genetic alterations patients have identified, CpG hypermethylation GSPT1 TMPRSS2:ERG gene fusion. Serum urine detection RNA biomarkers (eg, PCA3) tissue protein antibodies EPCA) are being evaluated prognostic tools. This article reviews some promising developments biomarkers.
参考文章(42)
Michael Lein, Eva-Maria Paul, Carsten Stephan, Hellmuth-Alexander Meyer, Klaus Jung, Stefan A. Loening, Glen Kristiansen, Serum (-5, -7) proPSA for Distinguishing Stage and Grade of Prostate Cancer Anticancer Research. ,vol. 27, pp. 1833- 1836 ,(2007)
Eddy S. Leman, Grant W. Cannon, Bruce J. Trock, Lori J. Sokoll, Daniel W. Chan, Leslie Mangold, Alan W. Partin, Robert H. Getzenberg, EPCA-2: a highly specific serum marker for prostate cancer. Urology. ,vol. 69, pp. 714- 720 ,(2008) , 10.1016/J.UROLOGY.2007.01.097
Mark Schrader, Jana Sachsinger, Markus Müller, Hans Krause, Rüdiger Heicappell, Kurt Miller, Carsten Goessl, Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids. Cancer Research. ,vol. 60, pp. 5941- 5945 ,(2000)
Lisa M. Sapinoso, Jessica Wang-Rodriguez, John B. Welsh, Christopher A. Moskaluk, Suzanne G. Kern, Andrew I. Su, Henry F. Frierson, Garret M. Hampton, Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Research. ,vol. 61, pp. 5974- 5978 ,(2001)
Siqun L Zheng, Bao-li Chang, Dennis A Faith, Jill R Johnson, Sarah D Isaacs, Gregory A Hawkins, Aubrey Turner, Kathy E Wiley, Eugene R Bleecker, Patrick C Walsh, Deborah A Meyers, William B Isaacs, Jianfeng Xu, None, Sequence Variants of α-Methylacyl-CoA Racemase Are Associated with Prostate Cancer Risk Cancer Research. ,vol. 62, pp. 6485- 6488 ,(2002)
William J. Catalona, Torsten Ehrig, Jeffrey Milbrandt, Peter A. Humphrey, Jeffrey A. Magee, Lawrence True, Sushama Patil, Mark A. Watson, Toshiyuki Araki, Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer Cancer Research. ,vol. 61, pp. 5692- 5696 ,(2001)
Carsten Stephan, Klaus Jung, Michael Lein, Eleftherios P. Diamandis, PSA and other tissue kallikreins for prostate cancer detection. European Journal of Cancer. ,vol. 43, pp. 1918- 1926 ,(2007) , 10.1016/J.EJCA.2007.06.006
R Thuret, K Chantrel-Groussard, A-R Azzouzi, J-M Villette, S Guimard, P Teillac, P Berthon, A Houlgatte, A Latil, O Cussenot, Clinical relevance of genetic instability in prostatic cells obtained by prostatic massage in early prostate cancer. British Journal of Cancer. ,vol. 92, pp. 236- 240 ,(2005) , 10.1038/SJ.BJC.6602311
Mohammad Obaidul Hoque, Ozlem Topaloglu, Shahnaz Begum, Rui Henrique, Eli Rosenbaum, Wim Van Criekinge, William H. Westra, David Sidransky, Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. Journal of Clinical Oncology. ,vol. 23, pp. 6569- 6575 ,(2005) , 10.1200/JCO.2005.07.009
RAJIV DHIR, BARBARA VIETMEIER, JULIE ARLOTTI, MARIE ACQUAFONDATA, DOUGLAS LANDSITTEL, ROBERT MASTERSON, ROBERT H. GETZENBERG, EARLY IDENTIFICATION OF INDIVIDUALS WITH PROSTATE CANCER IN NEGATIVE BIOPSIES The Journal of Urology. ,vol. 171, pp. 1419- 1423 ,(2004) , 10.1097/01.JU.0000116545.94813.27