25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis.

摘要: Objective: We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk symptomatic ischemic stroke in general population. Methods: We measured 10,170 individuals from population, Copenhagen City Heart Study. During 21 years follow-up, 1,256 and 164 persons developed hemorrhagic stroke, respectively. In a meta-analysis we included 10 studies, 58,384 participants, 2,644 events. Results: Stepwise decreasing were stepwise increasing both as function seasonally adjusted percentile categories clinical (p for trend ≤ 2 × 10−3). Cox regression model comparing between 1st 4th percentiles to 50th 100th percentiles, multivariate hazard ratio was 1.82 (95% confidence interval, 1.41–2.34). Comparing severe vitamin deficiency (<25.0nmol/l [<10.0ng/ml]) optimal status (≥75.0nmol/l [≥30.0ng/ml]), 1.36 (1.09–1.70). 25-Hydroxyvitamin not stroke. lowest versus highest quartile concentrations, odds 1.54 (1.43–1.65) corresponding 1.46 (1.35–1.58) prospective population studies. Interpretation: In this large population-based study, observed concentrations. This finding substantiated meta-analysis. ANN NEUROL 2013.