Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.
作者： M Pravenec , D Gauguier , J J Schott , J Buard , V Kren
DOI: 10.1172/JCI118244
关键词:
摘要: In the HXB and BXH recombinant inbred strains derived from spontaneously hypertensive rat normotensive Brown Norway rat, we determined strain distribution patterns of 500 genetic markers to scan rodent genome for quantitative trait loci regulating cardiac mass blood pressure. The spanned approximately 1,139 cM were tested correlations with left ventricular adjusted body weight, systolic, diastolic, mean arterial pressures. marker dopamine 1A receptor (Drd1a) on chromosome 17 showed strongest correlation heart weight (P = .00038, r -0.59) relationship was independent showing pressure D19Mit7 19 .0012, .55), D2N35 2 .0008, .56), Il6 4 .0018, .53), respectively. These studies demonstrate that can be effectively used scanning complex traits have revealed several regions may involved in control rat.
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