Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis.

摘要: This study is the first in literature to focus attention on possible immunotoxic effect of integerrimine N-oxide content butanolic residue (BR) Senecio brasiliensis, a poisonous hepatotoxic plant that contains pyrrolizidine alkaloids (PAs). PAs have been reported as pasture and food contaminant herbal medicine used worldwide are responsible for poisoning events livestock human beings. After extraction, BR extracted from brasiliensis was found contain approximately 70% by elemental spectral analyses ((1)H (13)C NMR), which administered adult male Wistar Hannover rats at doses 3, 6 9 mg/kg 28 days. Body weight gain, consumption, lymphoid organs, neutrophil analysis, humoural immune response, cellular response lymphocyte analysis were evaluated. Our showed could promote an impairment body interference with blood cell counts reducing T proliferative activity rats; however, no differences activities, lymphocytes phenotyping responses observed. It concluded here employed did not produce marked effects.