Biochemistry of transmembrane signaling mediated by trimeric G proteins.
作者： Hejnová L , Durchánková D , Drmota T , Svoboda P , Stöhr J
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摘要: Summary Many extracellular signals are at the cell surface received by specific receptors, which upon activation transduce information to appropriate cellular effector molecules via trimeric G proteins. The protein-mediated cascades ultimately lead highly refined regulation of systems such as sensory perception, growth, and hormonal regulation. Transmembrane signaling may be seriously deranged in various pathophysiological conditions. Over last two decades major experimental effort our group has been devoted better understanding molecular mechanisms underlying transmembrane regulated proteins closely related process desensitization hormone response. This review provides general about basic principles proteinregulated well contribution current progress field.
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