Characterization of primary prostate carcinoma by anti-1-amino-2-[(18)F] -fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) uptake.

摘要: Anti-1-amino-3-[(18)F] fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) is a synthetic amino positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim this study to correlate uptake anti-3-[(18)F] FACBC histology prostatectomy specimens patients undergoing radical and determine if correlates markers tumor aggressiveness such as Gleason score. Ten carcinoma pre-radical underwent 45 minute dynamic PET-CT pelvis after IV injection 347.8 ± 81.4 MBq FACBC. Each was co-registered separately acquired MR, divided into 12 sextants, analyzed visually for abnormal focal at 4, 16, 28, 40 min post-injection by single reader blinded histology. SUVmax per sextant total activity (TSA) also calculated. Histology scores were similarly recorded urologic pathologist imaging. Imaging histologic analysis then compared. In addition, 3 representative sextants from each chosen based on highest, lowest median immunohistochemical (IHC) Ki67, synaptophysin, P504s, chromogranin A, P53, androgen receptor, prostein. 79 had malignancy 41 benign. Highest combined sensitivity specificity 28 visual analysis; 81.3% 50.0% respectively. significantly higher (p<0.05) malignant (5.1±2.6 4 min; 4.5±1.6 16 4.0±1.3 3.8±1.0 min) compared non-malignant (4.0±1.9 3.5±0.8 3.4±0.9 3.3±0.9 min), though there overlap between sextants. correlated score all time points (r=0.28 r=0.42 r=0.46 r=0.48 min). There no significant correlation Ki-67 or other IHC markers. Since distinct separation levels, we believe that PET should not be used alone radiation therapy planning but may useful guide biopsy most aggressive lesion.