Importance of obesity, race and age to the cardiac structural and functional effects of hypertension

摘要: Abstract Objectives. The purpose of this study was to determine the effects obesity and its interaction with age, race magnitude blood pressure elevation in a large cohort patients mild moderate hypertension high prevalence left ventricular hypertrophy. Background. Obesity, age each have important on incidence severity may contribute cardiac manifestations hypertension. Methods. Left structure function were assessed two-dimensional targeted M-mode echocardiography 692 men (average 153/100 mm Hg), data compared relation (determined from body mass index), race, pressure, physical activity, plasma renin urinary sodium excretion, hematocrit, heart rate serum lipids. Results. hypertrophy common (630% increased mass, 22% electrocardiogram [ECG]). On multivariable regression analysis, index strongest predictor magnified slope mass. Despite greater ECG blacks (31%) than whites (10%), echocardiographic did not differ by race. However, septal, posterior relative wall thickness black white men. Conclusions. Obesity is clinical la men, even those sufficient be associated Moreover, independent systolic an amplified obesity. Although does affect or hypertrophy, thickness, itself unfavorable cardiovascular outcome.