Determination of the influence of stent strut thickness using the finite element method: implications for vascular injury and in-stent restenosis.

摘要: Many clinical studies, including the ISAR-STEREO trial, have identified stent strut thickness as an independent predictor of in-stent restenosis where thinner struts result in lower than thicker struts. The aim this study was to more conclusively identify mechanical stimulus for using results from such trials trial. environment arteries stented with thin and stents investigated numerical modelling techniques. Finite element models used trial were developed deployed idealised stenosed vessel geometries order compare each stent. stresses induced within vessels by these compared determine level vascular injury caused artery different thickness. found that when both expanded achieve same initial maximum diameter recoiled a greater extent resulting luminal gain but also wall, which is hypothesised be responsible outcome. This supports hypothesis develop response injury, high are good measure injury. points critical stress arteries, above aggressive healing leads vessels. Stents can designed reduce range preclinical tools modelling.