Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate

作者: Anna J Jasinska , Ivette Zelaya , Susan K Service , Christine B Peterson , Rita M Cantor

DOI: 10.1038/NG.3959

关键词:

摘要: By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated transcriptome resource produced the first catalog of quantitative trait loci (eQTLs) nonhuman primate model. This contains more significant eQTLs per sample than comparable human resources identifies sex- age-related patterns. Findings include master regulatory locus that likely has role immune function regulating hippocampal long noncoding RNAs (lncRNAs), whose correlates with volume. will facilitate investigation traits, including brain behavioral phenotypes relevant to neuropsychiatric disorders.

参考文章(65)
Melinda G Arnett, Lisa M Muglia, Gloria Laryea, Louis J Muglia, Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation Neuropsychopharmacology. ,vol. 41, pp. 245- 260 ,(2016) , 10.1038/NPP.2015.215
GTEx Consortium, Kristin G Ardlie, David S Deluca, Ayellet V Segrè, Timothy J Sullivan, Taylor R Young, Ellen T Gelfand, Casandra A Trowbridge, Julian B Maller, Taru Tukiainen, Monkol Lek, Lucas D Ward, Pouya Kheradpour, Benjamin Iriarte, Yan Meng, Cameron D Palmer, Tõnu Esko, Wendy Winckler, Joel N Hirschhorn, Manolis Kellis, Daniel G MacArthur, Gad Getz, Andrey A Shabalin, Gen Li, Yi-Hui Zhou, Andrew B Nobel, Ivan Rusyn, Fred A Wright, Tuuli Lappalainen, Pedro G Ferreira, Halit Ongen, Manuel A Rivas, Alexis Battle, Sara Mostafavi, Jean Monlong, Michael Sammeth, Marta Mele, Ferran Reverter, Jakob M Goldmann, Daphne Koller, Roderic Guigó, Mark I McCarthy, Emmanouil T Dermitzakis, Eric R Gamazon, Hae Kyung Im, Anuar Konkashbaev, Dan L Nicolae, Nancy J Cox, Timothée Flutre, Xiaoquan Wen, Matthew Stephens, Jonathan K Pritchard, Zhidong Tu, Bin Zhang, Tao Huang, Quan Long, Luan Lin, Jialiang Yang, Jun Zhu, Jun Liu, Amanda Brown, Bernadette Mestichelli, Denee Tidwell, Edmund Lo, Mike Salvatore, Saboor Shad, Jeffrey A Thomas, John T Lonsdale, Michael T Moser, Bryan M Gillard, Ellen Karasik, Kimberly Ramsey, Christopher Choi, Barbara A Foster, John Syron, Johnell Fleming, Harold Magazine, Rick Hasz, Gary D Walters, Jason P Bridge, Mark Miklos, Susan Sullivan, Laura K Barker, Heather M Traino, Maghboeba Mosavel, Laura A Siminoff, Dana R Valley, Daniel C Rohrer, Scott D Jewell, Philip A Branton, Leslie H Sobin, Mary Barcus, Liqun Qi, Jeffrey McLean, Pushpa Hariharan, Ki Sung Um, Shenpei Wu, David Tabor, Charles Shive, Anna M Smith, Stephen A Buia, Anita H Undale, Karna L Robinson, Nancy Roche, Kimberly M Valentino, Angela Britton, Robin Burges, Debra Bradbury, Kenneth W Hambright, John Seleski, Greg E Korzeniewski, Kenyon Erickson, Yvonne Marcus, Jorge Tejada, Mehran Taherian, Chunrong Lu, Margaret Basile, Deborah C Mash, Simona Volpi, Jeffery P Struewing, Gary F Temple, Joy Boyer, Deborah Colantuoni, Roger Little, Susan Koester, Latarsha J Carithers, Helen M Moore, Ping Guan, Carolyn Compton, Sherilyn J Sawyer, Joanne P Demchok, Jimmie B Vaught, Chana A Rabiner, Nicole C Lockhart, Kristin G Ardlie, Gad Getz, Fred A Wright, Manolis Kellis, Simona Volpi, Emmanouil T Dermitzakis, None, The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans Science. ,vol. 348, pp. 648- 660 ,(2015) , 10.1126/SCIENCE.1262110
Greg Gibson, Joseph E Powell, Urko M Marigorta, Expression quantitative trait locus analysis for translational medicine. Genome Medicine. ,vol. 7, pp. 60- 60 ,(2015) , 10.1186/S13073-015-0186-7
Robert C. Malenka, Steven E. Hyman, Eric J. Nestler, David M. Holtzman, Molecular Neuropharmacology: A Foundation for Clinical Neuroscience ,(2001)
Christine B. Peterson, Marina Bogomolov, Yoav Benjamini, Chiara Sabatti, Many Phenotypes Without Many False Discoveries: Error Controlling Strategies for Multitrait Association Studies Genetic Epidemiology. ,vol. 40, pp. 45- 56 ,(2016) , 10.1002/GEPI.21942
Marta Melé, Pedro G Ferreira, Ferran Reverter, David S DeLuca, Jean Monlong, Michael Sammeth, Taylor R Young, Jakob M Goldmann, Dmitri D Pervouchine, Timothy J Sullivan, Rory Johnson, Ayellet V Segrè, Sarah Djebali, Anastasia Niarchou, The GTEx Consortium, Fred A Wright, Tuuli Lappalainen, Miquel Calvo, Gad Getz, Emmanouil T Dermitzakis, Kristin G Ardlie, Roderic Guigó, None, The human transcriptome across tissues and individuals Science. ,vol. 348, pp. 660- 665 ,(2015) , 10.1126/SCIENCE.AAA0355
Wesley C. Warren, Anna J. Jasinska, Raquel García-Pérez, Hannes Svardal, Chad Tomlinson, Mariano Rocchi, Nicoletta Archidiacono, Oronzo Capozzi, Patrick Minx, Michael J. Montague, Kim Kyung, LaDeana W. Hillier, Milinn Kremitzki, Tina Graves, Colby Chiang, Jennifer Hughes, Nam Tran, Yu Huang, Vasily Ramensky, Oi-wa Choi, Yoon J. Jung, Christopher A. Schmitt, Nikoleta Juretic, Jessica Wasserscheid, Trudy R. Turner, Roger W. Wiseman, Jennifer J. Tuscher, Julie A. Karl, Jörn E. Schmitz, Roland Zahn, David H. O'Connor, Eugene Redmond, Alex Nisbett, Béatrice Jacquelin, Michaela C. Müller-Trutwin, Jason M. Brenchley, Michel Dione, Martin Antonio, Gary P. Schroth, Jay R. Kaplan, Matthew J. Jorgensen, Gregg W.C. Thomas, Matthew W. Hahn, Brian J. Raney, Bronwen Aken, Rishi Nag, Juergen Schmitz, Gennady Churakov, Angela Noll, Roscoe Stanyon, David Webb, Francoise Thibaud-Nissen, Magnus Nordborg, Tomas Marques-Bonet, Ken Dewar, George M. Weinstock, Richard K. Wilson, Nelson B. Freimer, The genome of the vervet (Chlorocebus aethiops sabaeus) Genome Research. ,vol. 25, pp. 1921- 1933 ,(2015) , 10.1101/GR.192922.115
Yu S. Huang, Vasily Ramensky, Susan K. Service, Anna J. Jasinska, Yoon Jung, Oi-Wa Choi, Rita M. Cantor, Nikoleta Juretic, Jessica Wasserscheid, Jay R. Kaplan, Matthew J. Jorgensen, Thomas D. Dyer, Ken Dewar, John Blangero, Richard K. Wilson, Wesley Warren, George M. Weinstock, Nelson B. Freimer, Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits BMC Biology. ,vol. 13, pp. 41- 41 ,(2015) , 10.1186/S12915-015-0152-2
Henriette Van Praag, Alejandro F Schinder, Brian R Christie, Nicolas Toni, Theo D Palmer, Fred H Gage, None, Functional neurogenesis in the adult hippocampus Nature. ,vol. 415, pp. 1030- 1034 ,(2002) , 10.1038/4151030A
S. C. Fears, W. P. Melega, S. K. Service, C. Lee, K. Chen, Z. Tu, M. J. Jorgensen, L. A. Fairbanks, R. M. Cantor, N. B. Freimer, R. P. Woods, Identifying Heritable Brain Phenotypes in an Extended Pedigree of Vervet Monkeys The Journal of Neuroscience. ,vol. 29, pp. 2867- 2875 ,(2009) , 10.1523/JNEUROSCI.5153-08.2009