Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
作者： Hidenori Ito , Rika Morishita , Koh-ichi Nagata
DOI: 10.3390/IJMS19072121
关键词:
摘要: Rhotekin is an effector protein for small GTPase Rho. This consists of a Rho binding domain (RBD), pleckstrin homology (PH) domain, two proline-rich regions and C-terminal PDZ (PSD-95, Discs-large, ZO-1)-binding motif. We, other groups, have identified various partners carried out biochemical cell biological characterization. However, the physiological functions Rhotekin, per se, are as yet largely unknown. In this review, we summarize known features its in neuronal tissues cancer cells.
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