Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer

作者: Sridharan Jeyamohan , Rajesh Kannan Moorthy , Mahesh Kumar Kannan , Antony Joseph Velanganni Arockiam

DOI: 10.1007/S10529-016-2102-7

关键词:

摘要: Objective To investigate the effect of parthenolide on apoptosis and autophagy and to study the role of the PI3K/Akt signaling pathway in cervical cancer. Results Parthenolide inhibits …

参考文章(26)
Antonio D. Cristofano, Barbara Pesce, Carlos Cordon-Cardo, Pier P. Pandolfi, Pten is essential for embryonic development and tumour suppression. Nature Genetics. ,vol. 19, pp. 348- 355 ,(1998) , 10.1038/1235
Lora Hedrick Ellenson, T.-C Wu, Focus on endometrial and cervical cancer Cancer Cell. ,vol. 5, pp. 533- 538 ,(2004) , 10.1016/J.CCR.2004.05.029
Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin, Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer. ,vol. 127, pp. 2893- 2917 ,(2010) , 10.1002/IJC.25516
Vivek Bhakta Mathema, Young-Sang Koh, Balkrishna Chand Thakuri, Mika Sillanpää, Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities. Inflammation. ,vol. 35, pp. 560- 565 ,(2012) , 10.1007/S10753-011-9346-0
Yajing Sun, Meijuan Zou, Chen Hu, Yansu Qin, Xiuming Song, Na Lu, Qinglong Guo, Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway Food and Chemical Toxicology. ,vol. 51, pp. 53- 60 ,(2013) , 10.1016/J.FCT.2012.09.012
Takahiro Shintani, Daniel J Klionsky, Autophagy in Health and Disease: A Double-Edged Sword Science. ,vol. 306, pp. 990- 995 ,(2004) , 10.1126/SCIENCE.1099993
Turgut Karlidag, Bengu Cobanoglu, Erol Keles, Hayrettin Cengiz Alpay, Ibrahim Ozercan, Irfan Kaygusuz, Sinasi Yalcin, Oner Sakallioglu, Expression of Bax, p53, and p27/kip in patients with papillary thyroid carcinoma with or without cervical nodal metastasis American Journal of Otolaryngology. ,vol. 28, pp. 31- 36 ,(2007) , 10.1016/J.AMJOTO.2006.06.008
Seong Hun Kim, Seung Ok Lee, Soo Teik Lee, Dae-Ghon Kim, Mi-Jin Lee, Woo Hyun Park, In Hee Kim, Sang Wook Kim, Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model Experimental and Molecular Medicine. ,vol. 44, pp. 448- 456 ,(2012) , 10.3858/EMM.2012.44.7.051
Siyuan Zhang, Choon-Nam Ong, Han-Ming Shen, None, Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells Cancer Letters. ,vol. 208, pp. 143- 153 ,(2004) , 10.1016/J.CANLET.2003.11.028
A D'Anneo, D Carlisi, M Lauricella, R Puleio, R Martinez, S Di Bella, P Di Marco, S Emanuele, R Di Fiore, A Guercio, R Vento, G Tesoriere, Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death and Disease. ,vol. 4, ,(2013) , 10.1038/CDDIS.2013.415