Hereditary breast cancer syndromes and genetic testing.
作者： Thereasa A. Rich , Ashley H. Woodson , Jennifer Litton , Banu Arun
DOI: 10.1002/JSO.23791
关键词:
摘要: Only 5% of breast cancers are explained by highly penetrant multisystem autosomal dominant hereditary disorders. Though another 20-30% has a familial presentation, the genetic and other etiologies still not well understood. Genetic testing is now widely available multiple professional societies have published guidelines for management. trends include utilization multi-gene panels that take advantage next-generation sequencing as low- moderate-penetrance susceptibility genes.
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