Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations

摘要: Abstract Objective Prophylactic surgical removal of the ovaries has been offered for many years as a potential preventative ovarian cancer in women deemed to be at increased hereditary risk this disease. Now, it is possible test specific mutations BRCA1 and BRCA2 genes that render members breast (HBOC) syndrome families susceptible cancer. Widespread intra-abdominal carcinomatosis, which mimics metastatic serous carcinoma, reported following oophorectomy individuals risk. This study was undertaken examine report particularly occurrence well other cancers, prophylactic patients who carry susceptibility assess cumulative risks disease order assist developing appropriate interventions, based on currently available information, counsel choose surgery, concerning prognosis, thereafter. Methods The Creighton University Hereditary Cancer Institute registry searched HBOC had undergone oophorectomy. histories results DNA testing carried their were recorded, tabulated examined, aggregate data are along with pertinent details those developed neoplastic diseases after All histologic cytologic materials diagnosed carcinomatosis reviewed, life-table calculations performed Results From 72 either or cancer-associated mutations, 238 recorded our between January 1985 December 2002. During mean follow-up 9.3 years, cancers 27 subjects, including 16 five carcinomatosis. Breast stage I 10 12 proven carriers mutations. cases carcinomas, all occurred mutation carriers. Histologic review prophylactically removed found borderline lesions two cases, one early stromal invasion. Two among 78 series treated before A 3.5% 3.9% calculated through 20 Conclusions Intra-abdominal only families, specifically deleterious below estimated published literature similar patients. tended small localized, most common malignancy