Childhood HIV-associated nephropathy: 36 years later.

摘要: HIV-associated nephropathy (HIVAN) predominantly affects people of African ancestry living with HIV who do not receive appropriate antiretroviral therapy (ART). Childhood HIVAN is characterized by heavy proteinuria and decreased kidney function. Kidney histology shows mesangial expansion, classic or collapsing glomerulosclerosis, microcystic renal tubular dilatation leading to enlargement. The pathogenesis involves the recruitment inflammatory cells infection epithelial cells. In addition, both viral genetic factors play key roles in this disease. Modern ART has improved outcome prevalence childhood HIVAN. However, physicians have had modest success providing chronic children adolescents, we continue see all over world. This article discusses progress made during last decade our understanding treatment HIVAN, placing particular emphasis on mechanisms that mediate cells, cytokines, HIV-Tat gene, Apolipoprotein-1 (APOL1) gene risk variants view large number at developing better prevention programs are needed eradicate