Helicobacter pylori vacA genotypes, cagA status and ureA-B polymorphism in isolates recovered from an Argentine population
作者： M Catalano , M Matteo , R.E Barbolla , D.E Jimenez Vega , O Crespo
DOI: 10.1016/S0732-8893(01)00307-8
关键词:
摘要: Several reports have evidenced geographic differences in the prevalence of vacA (vacuolating cytotoxin gene) alleles and cagA (cytotoxin-associated status among Helicobacter pylori isolates. We investigated occurrence these virulence-associated genes our isolates, their relationship with ulcer disease outcome. Besides, ureA-B polymorphism was studied. One hundred comprising 32 from patients (UD) 68 non-ulcer dyspepsia (NUD), were analyzed. Eighty-four percent isolates cagA-positive without statistically significant difference between UD or NUD. Genotype vacA-s1m1 predominant, although unlike other South American regions, subtype s1am1 higher than s1b. The multivariate model used to estimate predictive value for development disclosed infection vacA-s1am1 as only variable that increased risk onset. ureAB fingerprinting showed considerable genetic divergence however, confirmed certain DNA banding profiles are conserved worldwide.
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