P-Cell Stimulating Factor: Biochemistry, Biology, and Role in Oncogenesis

作者: John W. Schrader , Ian Clark-Lewis , Richard M. Crapper , Grace H. W. Wong , Sabariah Schrader

DOI: 10.1007/978-1-4684-4838-2_5

关键词:

摘要: The use of monoclonal lines T cells in the form T-cell hybridomas (Schrader et al., 1980a,b, 1982a; Harwell 1980; Schrader and Clark-Lewis, 1981), lymphomas (Ralph 1978; Hilfiker 1981; Golde Gillis Clark-Lewis 1982a, b), more recently (Staberet 1982; Kelso Prystowsky 1982) has established conclusively that lymphocyte is direct source factors with a wide range bioactivities. Our original observation on induction lymphokine synthesis by hybridoma, 123, indicated stimulation single cloned line resulted release multiple bioactivities 1980a). These included affecting B lymphocytes (T-cell replacing factor, TRF) growth factor (TCGF;now referred to as Interleukin-2, IL-2) 1980a, activities stimulating differentiation progenitors neutrophils, macrophages, megakaryocytes 1980a), an activity vitro production pluripotential hemopoietic stem b; 1982a).

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