Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.

作者: Traci M.Tanaka Hall , Jeffery A. Porter , Keith E. Young , Eugene V. Koonin , Philip A. Beachy

DOI: 10.1016/S0092-8674(01)80011-8

关键词:

摘要: … Hedgehog protein (Hh-C) possesses an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog … and report here its crystal structure. The Hh-C 17 …

参考文章(50)
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
Stephen F. Altschul, Warren Gish, Local alignment statistics. Methods in Enzymology. ,vol. 266, pp. 460- 480 ,(1996) , 10.1016/S0076-6879(96)66029-7
S. C. Ekker, R. T. Moon, D. P. Von Kessler, J. J. Lee, P. A. Beachy, Cheng-Jung Lai, L. L. Mcgrew, Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis Development. ,vol. 121, pp. 2337- 2347 ,(1995)
Jeffery A Porter, Stephen C Ekker, Woo-Jin Park, Doris P von Kessler, Keith E Young, Chien-Huan Chen, Yong Ma, Amina S Woods, Robert J Cotter, Eugene V Koonin, Philip A Beachy, Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell. ,vol. 86, pp. 21- 34 ,(1996) , 10.1016/S0092-8674(00)80074-4
Mary Hynes, Jeffery A. Porter, Chin Chiang, David Chang, Marc Tessier-Lavigne, Philip A. Beachy, Arnon Rosenthal, Induction of midbrain dopaminergic neurons by Sonic hedgehog Neuron. ,vol. 15, pp. 35- 44 ,(1995) , 10.1016/0896-6273(95)90062-4
J. A. Porter, K. E. Young, P. A. Beachy, Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development Science. ,vol. 274, pp. 255- 259 ,(1996) , 10.1126/SCIENCE.274.5285.255