Mechanics of motility initiation and motility arrest in crawling cells

摘要: Abstract Motility initiation in crawling cells requires transformation of a symmetric state into polarized state. In contrast, motility arrest is associated with re-symmetrization the internal configuration cell. Experiments on keratocytes suggest that polarization triggered by increased contractility motor proteins but conditions remain unknown. this paper we show if adhesion extra-cellular substrate sufficiently low, progressive intensification motor-induced contraction may be responsible for both transitions: from static (symmetric) to motile (polarized) at lower threshold and back higher threshold. Our model lamellipodial cell based 1D projection complex intra-cellular dynamics direction locomotion. interest analytical transparency also neglect active protrusion view as passive. Despite unavoidable oversimplifications these assumptions, reproduces quantitatively pattern fish reveals crucial role played nonlocal feedback between mechanics transport agents. A prediction can stop re-symmetrize when increases far beyond still awaits experimental verification.