Milk-derived multi-fluorescent graphene quantum dot-based cancer theranostic system
作者： Mukeshchand Thakur , Ashmi Mewada , Sunil Pandey , Mustansir Bhori , Kanchanlata Singh
DOI: 10.1016/J.MSEC.2016.05.007
关键词:
摘要: Abstract An economical green-chemistry approach was used for the synthesis of aqueous soluble graphene quantum dots (GQDs) from cow milk simultaneous imaging and drug delivery in cancer. The GQDs synthesized using one-pot microwave-assisted heating were multi-fluorescent, spherical shape having a lateral size ca. 5 nm. role processing parameters such as time ionic strength showed profound effect on photoluminescence properties GQDs. N-doped oxygen-rich confirmed by X-ray photoelectron spectroscopy (XPS) analysis. Cysteamine hydrochloride (Cys) to attach an anti-cancer berberine (BHC) forming GQDs@Cys-BHC complex with c.a. 88% loading efficiency. In vitro release studied at acidic-basic environment kinetics pharmacokinetic statistical models. biocompatible L929 cells whereas theranostic potent cytotoxic different cancerous cell line models: cervical cancer lines HeLa breast MDA-MB-231 Trypan blue MTT-based assays. Furthermore, multi-excitation based cellular bioimaging demonstrated confocal laser scanning microscopy (CLSM) fluorescence well complex. Thus, (therapeutic) (diagnostic) are thought have potential application therapy.
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