Age-Related Testosterone Decline is due to Waning of Both Testicular and Hypothalamic-Pituitary Function
作者： Ron Golan , Jason M. Scovell , Ranjith Ramasamy
DOI: 10.3109/13685538.2015.1052392
关键词:
摘要: … secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels … the current controversy regarding testosterone-replacement therapy in aging males. …
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sci-hub.se 参考文章(36)
R Paniagua, M Nistal, J Regadera, Testis, epididymis, and spermatic cord in elderly men. Correlation of angiographic and histologic studies with systemic arteriosclerosis. Archives of Pathology & Laboratory Medicine. ,vol. 109, pp. 663- 667 ,(1985)
Barry R. Zirkin, Haolin Chen, Ilpo Huhtaniemi, Matthew P. Hardy, Age-Related Decreased Leydig Cell Testosterone Production in the Brown Norway Rat Journal of Andrology. ,vol. 15, pp. 551- 557 ,(1994) , 10.1002/J.1939-4640.1994.TB00498.X
Jakob E. Lackner, Ernst Rücklinger, Georg Schatzl, Gerhard Lunglmayr, Christian W. Kratzik, Are there symptom‐specific testosterone thresholds in aging men? BJUI. ,vol. 108, pp. 1310- 1315 ,(2011) , 10.1111/J.1464-410X.2010.09986.X
Ali A. Dabaja, Campbell F. Bryson, Peter N. Schlegel, Darius A. Paduch, The effect of hypogonadism and testosterone‐enhancing therapy on alkaline phosphatase and bone mineral density BJUI. ,vol. 115, pp. 480- 485 ,(2015) , 10.1111/BJU.12870
Brett T. Marck, David A. Gruenewald, Alvin M. Matsumoto, Michael A. Naai, Age‐Related Decrease in Hypothalmic Gonadotropin‐Releasing Hormone (GnRH) Gene Expression, But Not Pituitary Responsiveness to GnRH, in the Male Brown Norway Rat Journal of Andrology. ,vol. 21, pp. 72- 84 ,(2000) , 10.1002/J.1939-4640.2000.TB03278.X
J D Veldhuis, R J Urban, G Lizarralde, M L Johnson, A Iranmanesh, Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men. The Journal of Clinical Endocrinology and Metabolism. ,vol. 75, pp. 707- 713 ,(1992) , 10.1210/JCEM.75.3.1517359
R J Urban, J D Veldhuis, R M Blizzard, M L Dufau, Attenuated release of biologically active luteinizing hormone in healthy aging men. Journal of Clinical Investigation. ,vol. 81, pp. 1020- 1029 ,(1988) , 10.1172/JCI113412
Gideon Sartorius, Sasa Spasevska, Amanda Idan, Leo Turner, Elise Forbes, Anna Zamojska, Carolyn A. Allan, Lam P. Ly, Ann J. Conway, Robert I. McLachlan, David J. Handelsman, Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self‐reporting very good health: the healthy man study Clinical Endocrinology. ,vol. 77, pp. 755- 763 ,(2012) , 10.1111/J.1365-2265.2012.04432.X
Touichiro Takizawa, Shigeru Hatakeyama, AGE‐ASSOCIATED CHANGES IN MICROVASCULATURE OF HUMAN ADULT TESTIS Pathology International. ,vol. 28, pp. 541- 554 ,(1978) , 10.1111/J.1440-1827.1978.TB00894.X
Stephen J. Winters, Richard J. Sherins, Philip Troen, The gonadotropin-suppressive activity of androgen is increased in elderly men Metabolism-clinical and Experimental. ,vol. 33, pp. 1052- 1059 ,(1984) , 10.1016/0026-0495(84)90237-3