Familial aggregation of hematopoietic malignancies and risk of non-Hodgkin's lymphoma.

摘要: Examination of risk factors that may be responsible for the increasing incidence non-Hodgkin's lymphoma (NHL) over past few decades would incomplete without considering familial aggregation hematolymphoproliferative neoplasms and relative contributions heredity environment to etiology NHL. Reports families with two or more NHL cases sometimes additional members affected by other hematopoietic malignancies (multiple-case families) are summarized, as findings from surveys quantitative estimates population-based studies aggregation. The notable occurrence various immunological abnormalities among multiplecase family related is underscored, diversity types lymphoproliferative close relatives in these families. Preliminary evidence suggesting multiple-case susceptible certain environmental exposures presented. An international registry such (particularly those identified studies) proposed clarify interrelationship genetic, familial,