Heritability of Hematologic Malignancies: From Pedigrees to Genomics
作者： Jane E. Churpek , Kenan Onel
DOI: 10.1016/J.HOC.2010.06.001
关键词: Myeloid 、 Bioinformatics 、 Pedigree chart 、 Genetic variation 、 Germline 、 Cancer 、 Medicine 、 Candidate gene 、 Heritability 、 Genomics 、 Genetics
摘要: Many hematologic malignancies have an underlying heritable component. Although not as well characterized the acquired genetic abnormalities that define important prognostic and therapeutic subgroups of myeloid lymphoid neoplasms, investigations are beginning to unravel role germline variation in predisposition malignancies. Information gained from study striking family pedigrees, epidemiologic data, candidate genes now being combined with unbiased genome-wide outline network contribute malignancy risk. This article reviews current understanding heritability genomics era.
sci-hub.se 参考文章(203)
Richard A. Larson, Yunxia Wang, Mekhala Banerjee, Joseph Wiemels, Christine Hartford, Michelle M. Le Beau, Martyn T. Smith, Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia. Blood. ,vol. 94, pp. 803- 807 ,(1999) , 10.1182/BLOOD.V94.2.803
Soon Ha Kim, Eun Young Choi, Young Kee Shin, Tae Jin Kim, Doo Hyun Chung, Sung Ik Chang, Noe Kyeong Kim, Seong Hoe Park, Generation of Cells With Hodgkin's and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2) Blood. ,vol. 92, pp. 4287- 4295 ,(1998) , 10.1182/BLOOD.V92.11.4287
Letter: Bone-marrow responses in polycythemia vera. The New England Journal of Medicine. ,vol. 290, pp. 1382- ,(1974) , 10.1056/NEJM197406132902419
Constantin A. Dasanu, Doru T. Alexandrescu, Risk for Second Nonlymphoid Neoplasms in Chronic Lymphocytic Leukemia MedGenMed : Medscape general medicine. ,vol. 9, pp. 35- ,(2007)
JP Baak, PM Kluin, P van der Valk, JM Walboomers, CJ Meijer, JJ Oudejans, NM Jiwa, JA Kummer, A Horstman, W Vos, Analysis of major histocompatibility complex class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus-positive and -negative Hodgkin's disease. Blood. ,vol. 87, pp. 3844- 3851 ,(1996) , 10.1182/BLOOD.V87.9.3844.BLOODJOURNAL8793844
AM Taylor, JA Metcalfe, J Thick, YF Mak, Leukemia and lymphoma in ataxia telangiectasia Blood. ,vol. 87, pp. 423- 438 ,(1996) , 10.1182/BLOOD.V87.2.423.BLOODJOURNAL872423
W. Klitz, A. B. Begovich, N. Fildes, S. J. Horning, C. L. Aldrich, Localization of predisposition to Hodgkin disease in the HLA class II region. American Journal of Human Genetics. ,vol. 54, pp. 497- 505 ,(1994)
Peter H Wiernik, Leukaemias and Lymphomas eLS. ,(2001) , 10.1038/NPG.ELS.0001895
Martha S. Linet, Linda M. Pottern, Familial aggregation of hematopoietic malignancies and risk of non-Hodgkin's lymphoma. Cancer Research. ,vol. 52, pp. 5468- 5473 ,(1992)
Elias Campo, N Lee Harris, Elaine S Jaffe, Stefano A Pileri, Harald Stein, Jurgen Thiele, James W Vardiman, None, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues ,(2017)