An Integrated Genomic Approach to the Assessment and Treatment of Acute Myeloid Leukemia

摘要: Traditionally, new scientific advances have been applied quickly to the leukemias based on ease with which relatively pure samples of malignant cells can be obtained. Currently, our arsenal approaches used characterize an individual's acute myeloid leukemia (AML) combines hematopathologic evaluation, flow cytometry, cytogenetic analysis, and molecular studies focused a few key genes. The advent high-throughput methods capable full-genome evaluation presents options for revolutionary change in way we diagnose, characterize, treat AML. Next-generation DNA sequencing techniques allow full cancer genome or transcriptome, hope that this will affordable routine clinical care within decade. Microarray-based testing define gene miRNA expression, methylation patterns, chromosomal imbalances, predisposition disease chemosensitivity. vision future entails integrated automated approach these analyses, bringing possibility formulating individualized treatment plan days patient's initial presentation. With expectations comes such lead decreased toxicities prolonged survival patients.