Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury.
作者： Alex C. Chin , Charles A. Parkos
DOI: 10.1146/ANNUREV.PATHOL.2.010506.091944
关键词:
摘要: AbstractNeutrophil (also known as polymorphonuclear leukocyte, or PMN) transepithelial migration and accumulation at mucosal surfaces is a hallmark of many inflammatory conditions. This process correlates directly with clinical disease activity epithelial injury. Currently, the mechanisms that define PMN interactions during an response are not completely understood. review provides overview consequences infiltration into tissues highlights molecular details transmigration. A better understanding this will likely provide new insights developing organ-specific treatment strategies to reduce deleterious inflammation.
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