Estimation of Skin Target Site Acyclovir Concentrations Following Controlled (Trans)dermal Drug Delivery in Topical and Systemic Treatment of Cutaneous HSV-1 Infections in Hairless Mice
作者： George Imanidis , Wei‐qi Song , Paul H. Lee , Muh‐Hwan Su , Earl R. Kern
关键词:
摘要: … This experimental approach followed by appropriate evalu… , C*, at the skin target site is introduced with the aim to es— … The basal cell layer of the epidermis is used as the skin target …
springer.com
sci-hub.se 参考文章(15)
W B Mahony, B A Domin, R T McConnell, T P Zimmerman, Acyclovir transport into human erythrocytes. Journal of Biological Chemistry. ,vol. 263, pp. 9285- 9291 ,(1988) , 10.1016/S0021-9258(19)76537-5
Paul H. Lee, Muh‐Hwan Su, Earl R. Kern, William I. Higuchi, Novel animal model for evaluating topical efficacy of antiviral agents: flux versus efficacy correlations in the acyclovir treatment of cutaneous herpes simplex virus type 1 (HSV-1) infections in hairless mice. Pharmaceutical Research. ,vol. 9, pp. 979- 989 ,(1992) , 10.1023/A:1015838007864
A. M. Al-Hasania, I. G. Barton, L. S. Al-Omer, G. R. Kinghorn, C. W. Potter, Susceptibility of HSV strains from patients with genital herpes treated with various formulations of acyclovir. Journal of Antimicrobial Chemotherapy. ,vol. 18, pp. 113- 119 ,(1986) , 10.1093/JAC/18.SUPPLEMENT_B.113
Colin McLaren, Cornelia D. Sibrack, David W. Barry, Spectrum of sensitivity to acyclovir of herpes simplex virus clinical isolates The American Journal of Medicine. ,vol. 73, pp. 376- 379 ,(1982) , 10.1016/0002-9343(82)90126-7
Fusao Komada, Georg Imanidis, Masaharu Mlyajima, Teruo Okano, Manzer J. Durrani, William I. Higuchi, Sung-Wan Kim, William M. Shannon, David C. Baker, Design of 9-β-D-Arabinofuranosyladenine (Ara-A) Transdermal Delivery System for Animal Studies: Regulation of Drug Concentration In Vivo Journal of Pharmaceutical Sciences. ,vol. 80, pp. 935- 941 ,(1991) , 10.1002/JPS.2600801007
R. J. Klein, A. E. Friedman-Kien, E. Brady, Herpes Simplex Virus Skin Infection in Hairless Mice: Treatment with Antiviral Compounds Antimicrobial Agents and Chemotherapy. ,vol. 5, pp. 318- 322 ,(1974) , 10.1128/AAC.5.3.318
Donald F. Smee, Nancy L. Campbell, Thomas R. Matthews, Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2′-fluoropyrimidine nucleosides Antiviral Research. ,vol. 5, pp. 259- 267 ,(1985) , 10.1016/0166-3542(85)90040-3
Miyajima Masaharu, Okano Teruo, Sung Wan Kim, William I Higuchi, None, Preformulation of an Ara-A transdermal delivery system: Membrane fabrication and characterization Journal of Controlled Release. ,vol. 5, pp. 179- 186 ,(1987) , 10.1016/0168-3659(87)90009-5
Akinori Gonsho, George Imanidis, Peggy Vogt, Earl R. Kern, Hideya Tsuge, Muh-Hwan Su, Seung-Ho Choi, William I. Higuchi, Controlled (trans) dermal delivery of an antiviral agent (acyclovir). I: An in vivo animal model for efficacy evaluation in cutaneous HSV-1 infections International Journal of Pharmaceutics. ,vol. 65, pp. 183- 194 ,(1990) , 10.1016/0378-5173(90)90142-Q
Paulo de Miranda, Harvey C. Krasny, Donna A. Page, Gertrude B. Elion, Species differences in the disposition of acyclovir The American Journal of Medicine. ,vol. 73, pp. 31- 35 ,(1982) , 10.1016/0002-9343(82)90059-6