Host/Pathogen Interactions in Fungal Keratitis

摘要: There are multiple overlapping mechanisms for protection against corneal fungal infections. The source of infection is nearly always exogenous and due to environmental molds (e.g., Fusarium Aspergillus) or cutaneous yeasts Candida albicans). Therefore, intact anatomical barriers effective tear function crucial first lines defense. Antimicrobial substances such as lysozyme, lactoferrin, lipocalin, defensins which found in tears and/or produced by cells constitute an additional line Finally, the presence fungi products at surface triggers signaling pathways within resident that then activate direct indirect cellular responses. These include recruitment neutrophils T site activation antifungal mechanisms. Taken a whole, host defenses ocular provide multilayered overwhelmingly shield keratitis.