Assessment of bronchodilator response in children with asthma. Dutch CNSLD Study Group

摘要: The bronchodilator response (BDR) in forced expiratory volume one second (FEV1) is routinely assessed to estimate the reversibility of airways obstruction. However, there no consensus on how BDR should be expressed, and recommendations applying children are lacking. Similarly, relationship between nonspecific bronchial hyperresponsiveness histamine (BHR) has not been elucidated. These questions were addressed 116 children, 7-16 yrs age, with stable asthma after withdrawal all pulmonary maintenance medication. Inclusion criteria an initial FEV1 55-90% predicted, and/or FEV1/forced vital capacity (FVC) 50-75%, as well a fall 20% or more when challenged up 150 micrograms histamine. change (delta FEV1) 20 min inhalation 800 salbutamol was expressed four ways: absolute difference FEV1(l)), percentage predicted FEV1%pred) FEV1%init), deficit FEV1%(pred-init)). delta FEV1%init FEV1%pred related age stature children; FEV1%(pred-init) stature, whilst FEV1(l) both stature. All indices correlated FEV1. this artefact introduced by relating value, rather than mean final value. In fact, BDR, FEV1%pred, only slightly greater lowest airway calibre (p = 0.08), unlike FEV1%init. weakly BHR.(ABSTRACT TRUNCATED AT 250 WORDS)