Slow Reacting Substances

摘要: The in vitro stimulation of smooth muscle preparations has been utilized to identify and initially characterize biologically active substances since the early work on action β-imidazolylethylamine (Dale Laidlaw, 1910). term “slow reacting substance” was introduced by Feldberg Kellaway (1938) describe activity material obtained during perfusion guinea pig lung with cobra venom. Anaphylactic shock same tissue (Kellaway Trethewie, 1940) produced a similar activity. In addition, cat paw condensation product p-methoxyphenethylmethylamine formaldehyde (compound 48/80) resulted release stimulating principle (Paton, 1951; Chakravarty et al, 1959). These three slow (SRSs) are generated unique methods but have common ileum (Vogt, 1969). physicochemical characterization SRSs, although not complete, demonstrated both distinct properties. Additional naturally occurring that SRSs include substance P (von Euler Gaddum, 1931), which is extractable from nervous intestinal (Lembeck Zetler, 1971) now identified as an undecapeptide 1340 mol wt (Chang Leeman, 1970), prostaglandins their precursors, Darmstoff other lipid- soluble acids 1958). compounds biological interest possible relationship will be reviewed this Chapter.