Variants of human papillomavirus type 16 predispose toward persistent infection

摘要: A cohort study of 292 Chinese women was conducted to determine the relationship between human papillomavirus (HPV) type 16 variants and persistent viral infection. Enrolled patients were HPV16 positive had both normal cytology histology. Flow-through hybridization gene chip technology used identify HPV type. PCR sequencing assay performed find E2, E6 E7 variants. The associations these infection analyzed by Fisher's exact test. It found that T178G, T350G A442C in gene, as well C3158A G3248A E2 associated with No link observed Our findings suggest detection specific would help who are at high risk for persistence development cervical neoplasia.