Perfluorooctane sulfonate induces apoptosis of hippocampal neurons in rat offspring associated with calcium overload
作者： Yu Wang , Huimin Zhao , Qian Zhang , Wei Liu , Xie Quan
DOI: 10.1039/C4TX00177J
关键词:
摘要: The purpose of this research is to investigate the effects perfluorooctane sulfonate (PFOS) on neuronal apoptosis in hippocampus rat offspring, and elucidate underlying mechanisms associated with calcium homeostasis. A cross-fostering model was established, enabling evaluation prenatal postnatal exposure. Internal exposure measured via PFOS concentration analysis serum hippocampus. Cell neurons identified together measurement intracellular free ([Ca2+]i). Continuous both period induced increasing neurocytes. Meanwhile, [Ca2+]i increased a dose dependent manner continuous groups groups. Furthermore, expression related genes can be used for mechanistic apoptotic by PFOS. Both linked gene-2 (alg-2) death-associated protein kinase (dapk2) were up-regulated, especially day (PND) 35. B-cell CLL/lymphoma (Bcl-2) also significantly up-regulated PND7 PND35. Overall results indicated that caused hippocampus, where overload acted as potential mechanism. resulted long-lasting homeostasis genes’ regulated signaling highlighting developmental neurotoxicity risk fetal
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