Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*2402, the most common HLA class I allele in East Asia
作者： Yuji Sobao , Kazuhiro Sugi , Hiroko Tomiyama , Satoru Saito , Shigetoshi Fujiyama
DOI: 10.1016/S0168-8278(01)00048-4
关键词:
摘要: Abstract Background/Aims : The aim of this study was to identify and characterize hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTL) epitopes presented by human leukocyte antigen (HLA)-A*2402, most common HLA class I allele in East Asia. Methods HLA-A*2402-restricted CTL were identified reverse immunogenetics. Immunogenecity these investigated using peripheral blood mononuclear cell (PBMC) from HLA-A24 + patients with acute B. Results An HLA-A*2402 stabilization assay demonstrated that 36 63 HBV peptides carrying anchor residues have high- medium-HLA-A*2402 binding affinity. Two (C117–125 P756–764) the induced peptide-specific CTLs. clones lines specific for killed recombinant vaccinia virus-infected target cells expressing HLA-A*2402, indicating two are HLA-A*2402. These able induce CTLs 7 11 12 B, respectively. Conclusions We immunodominant restricted Because is Asia, a region which there approximately 200 million carriers, will be useful analysis responses
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sci-hub.se 参考文章(36)
Hans Georg Rammensee, Hajime Shiga, Masafumi Takiguchi, Kiyoshi Miwa, Satoshi Kimura, Yuji Takamiya, Takashi Gojoubori, Hiroko Tomiyama, Tatsuo Shioda, Shinichi Oka, Yumi Yamaguchi, Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules AIDS. ,vol. 10, pp. 1075- 1083 ,(1996)
B. Rehermann, F. V. Chisari, Cell mediated immune response to the hepatitis C virus. Current Topics in Microbiology and Immunology. ,vol. 242, pp. 299- 325 ,(2000) , 10.1007/978-3-642-59605-6_14
Dominique Charron, HLA : genetic diversity of HLA functional and medical implication EDK Medical and Scientific International ; c1997. ,(1997)
H Grey, G Ishioka, F V Chisari, J Fikes, A Sette, C Crimi, B D Livingston, R W Chesnut, The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection. Journal of Immunology. ,vol. 159, pp. 1383- 1392 ,(1997)
V Barnaba, F Balsano, A Alberti, A Franco, R Benvenuto, C Balsano, Recognition of hepatitis B virus envelope proteins by liver-infiltrating T lymphocytes in chronic HBV infection. Journal of Immunology. ,vol. 143, pp. 2650- 2655 ,(1989)
Masafumi Takiguchi, Kiyoshi Miwa, Shinichi Oka, Yutaro Kaneko, Aikichi Iwamoto, Hiroko Tomiyama, Yuki Ikeda-Moore, Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1. Journal of Immunology. ,vol. 159, pp. 6242- 6252 ,(1997)
A Bertoletti, F V Chisari, A Penna, S Guilhot, L Galati, G Missale, P Fowler, H J Schlicht, A Vitiello, R C Chesnut, Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. Journal of Virology. ,vol. 67, pp. 2376- 2380 ,(1993) , 10.1128/JVI.67.4.2376-2380.1993
H. M. Grey, F. V. Chisari, R. Nayersina, M.-F. Del Guercio, C. Oseroff, S. Southwood, L. Yuan, P. Fowler, R. T. Kubo, A. Sette, B. Reherman, A. Vitiello, J. Ruppert, C. J. M. Melief, J. Sidney, R. W. Chesnut, W. M. Kast, The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. Journal of Immunology. ,vol. 153, pp. 5586- 5592 ,(1994)
F V Chisari, R Nayersina, S Guilhot, G Missale, P Fowler, A G Redeker, R Chesnut, A Cerny, H J Schlicht, J L Person, A Vitiello, HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. Journal of Immunology. ,vol. 150, pp. 4659- 4671 ,(1993)
Hajime Shiga, Masafumi Takiguchi, Kiyoshi Miwa, Yutaro Kaneko, Aikichi Iwamoto, Yuki Ikeda Moore, Hiroko Tomiyama, Shinichi Oka, Evidence of presentation of multiple HIV-1 cytotoxic T lymphocyte epitopes by HLA-B*3501 molecules that are associated with the accelerated progression of AIDS. Journal of Immunology. ,vol. 158, pp. 5026- 5034 ,(1997)