Intracoronary acid infusion as an alternative to ischemic postconditioning in pigs.

摘要: Previous studies suggested that prolongation of acidosis during reperfusion is protective and may be an important mechanism postconditioning protection. The aim this study was to analyze the therapeutic value intervention in vivo coronary reperfusion, compare it with ischemic postconditioning. Pigs were submitted 48 or 60 min ischemia 2 h reperfusion. Animals allocated either intracoronary infusion Krebs solution at dose duration previously described as optimal rat hears (pH 6.4 for first 3 reperfusion), (8 cycles 30 s ischemia/reperfusion) their respective control groups (n = 9-11 per group). Neither nor modified infarct size after compared pooled controls. In contrast, animals occlusion, reduced both by acid (57.92 +/- 18.15% 56.91 7.50 vs. 75.37 9.29% controls, P < 0.01), despite having similar areas risk. However, increased incidence ventricular fibrillation observed pigs reperfused (11 out 20 19 pigs, 0.05). conclusion, offered protection against cell death only prolonged occlusion. Both interventions equally effective, but associated high risk fibrillation. These results are strongly translation acidic patients acute myocardial infarction.