Expression of Estrogen Receptor-β Messenger Ribonucleic Acid in Oxytocin and Vasopressin Neurons of the Rat Supraoptic and Paraventricular Nuclei1
作者： Erik Hrabovszky , Imre Kalló , Tibor Hajszán , Paul J. Shughrue , István Merchenthaler
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摘要: The regulatory actions of estrogen on magnocellular oxytocin (OT) and vasopressin (VP) neurons the paraventricular (PVN) supraoptic (SON) nuclei are well documented. To date it is still debated whether effect estrogens exerted directly or mediated by estrogen-sensitive interneurons. Previous immunocytochemical (ICC) in situ hybridization (ISH) studies detected either low levels absence classical receptor (ER-α) PVN SON rat. present experiments using a combined ICC ISH method were undertaken to examine expression recently cloned beta form ER (ER-β) OT- VP-immunoreactive (IR) neuronal systems rat hypothalamus. results demonstrate that highest cellular ER-β messenger RNA (mRNA) OT-IR can be visualized caudal portion an area ventro-medial central core VP-IR cells. These previously shown project caudally brain stem spina...
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