Genetics of susceptibility of rats to trigeminal schwannomas induced by neonatal administration of N-ethyl-N-nitrosourea.

摘要: A genetic analysis was done on the induction of trigeminal schwannomas by N-ethyl-N-nitrosourea [(ENU) CAS: 759-73-9] in susceptible LE rats, resistant WF and their F1, F2, reciprocal backcross hybrids. Both sexes all strains were given a neonatal sc injection 40 mg ENU/kg body weight sacrificed at 6 months after treatment. Many neurogenic tumors induced central nervous system rats. However, incidence rats 93% males 86% females, whereas 24% 20% females. F1 F2 hybrids showed an intermediate susceptibility (62 82% males, 79 26 38% 65 77% females). The backcrossed to high (90 100% 77 83% females), low (35 11 7% findings suggest that ENU does not result from expression genes are simple dominant or recessive genes. model involving three independently segregating loci may explain experimental results. In particularly hybrids, more than females ENU.