Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association
作者： M. Hatakeyama , T. Kono , N. Kobayashi , A. Kawahara , S. Levin
关键词:
摘要: In the interleukin-2 (IL-2) system, intracellular signal transduction is triggered by beta chain of IL-2 receptor (IL-2R beta); however, responsible signaling mechanism remains unidentified. Evidence for formation a stable complex IL-2R and lymphocyte-specific protein tyrosine kinase p56lck presented. Specific association sites were identified in catalytic domain cytoplasmic beta. As result interaction, became phosphorylated vitro p56lck. Treatment T lymphocytes with promotes activity. These data suggest participation as critical molecule downstream via novel interaction.
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